Valium: instructions for use, analogs, composition, indications, how to buy Valium 2019

World statistics indicate that the increasing complexity of society and some socio-economic factors have recently provoked an increase in anxiety disorders and other mental illnesses (affective disorders) in the population. According to estimates, at least 500 million people in the world suffer from various mental disorders. In many countries, 30–40% of people with disabilities have lost their ability to work due to mental health problems. Epidemiological forecasts indicate that in the future the magnitude of this problem is very likely to increase due to the influence of various factors, including such as an increase in the life expectancy of people with mental disorders and disability, as well as an increase in the number of elderly people, among which especially high risk of mental disorders.

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Anxiety disorders constitute one of the largest categories of affective disorders. The main symptoms of these disorders are anxiety, fear, fatigue, concentration disorder, irritability, muscle tension, and sleep disorder. According to world statistics, 10.4-28.8% of the population experiences some kind of anxiety disorder, while the incidence rate for the year is on average about 18% among people over 18 years of age.

Depressive and anxiety disorders entail adverse consequences of a medical, personal, and social nature. According to numerous epidemiological studies conducted in Western Europe and the United States of America (USA), anxiety disorders are a group of mental disorders with the longest duration of the disease and the earliest debut (11 years). In young patients, the comorbidity of anxiety disorder is an important prognostic indicator that determines a more severe course of depression, chronic disease, an increase in suicidal risk, a longer course of treatment and a decrease in the effectiveness of treatment, the same relationships are observed in diseases of middle and old age. In addition to the associated course with depression, anxiety disorders are accompanied by other diseases: asthma, tumor processes, hypertension, migraine, and diseases of the gastrointestinal tract.

Valium is one of the group of main tranquilizers that have been widely used in any branch of medical practice. To buy Valium is necessary to enhance the effect that sleeping pills, drugs, antipsychotics, analgesics, and alcohol have on people.

Pharmacologic effect

Valium has anxiolytic, anticonvulsant, muscle relaxant (central), sedative, and hypnotic. Anxiolytic activity is manifested by the ability to stop internal anxiety, fear, anxiety, and tension. Valium has a dose-dependent effect on the central nervous system: in small (2-15 mg per day) - stimulant, in large (15 mg per day or more) - sedative. The central muscle relaxant effect is associated with inhibition of polysynaptic spinal reflexes. It causes a decrease in blood pressure (weak sympatholytic), expansion of the coronary vessels and increases the resistance of the brain to hypoxia. The drug increases the threshold of pain sensitivity. It has pronounced antiparoxysmal and anticonvulsant effects, which are manifested by the suppression of sympathoadrenal and parasympathetic paroxysms. After oral administration, about 75% of the dose is absorbed. The maximum concentration is reached after 1-1.5 hours. It undergoes biotransformation in the liver with the formation of active metabolites. The half-life in infants is about 30 hours, in adults and the elderly - 48 and 100 hours, respectively. With liver pathology, the half-life is prolonged to 4 days. It is excreted mainly by the kidneys (about 90%) in the form of conjugates, less than 10% with feces, up to 2% with urine unchanged.

Indications for use

Valium is used to treat neurosis, neurasthenia, hysteria, reactive depression, agoraphobia, insomnia associated with a violation of the falling asleep phase, Meniere's disease, spastic paralysis, withdrawal symptoms in patients with alcoholism, status epilepsy, epilepsy, sedation before surgery and endoscopic procedures; LSD poisoning.

Contraindications

To buy Valium is contraindicated in diazepam hypersensitivity, acute liver, and kidney diseases with impaired function, myasthenia gravis, angle-closure glaucoma, I trimester of pregnancy, breast-feeding.

Side effect

There are side effects which can occur addiction, paradoxical reactions (the development of anxiety, hallucinations, convulsions, insomnia), a decrease in the speed of reactions and concentration of attention, drowsiness, worsening of short-term memory, ataxia, dysarthria, headache, dizziness, hypotension, bradycardia, with prolonged use, liver and kidney damage, atony intestines, decreased libido and potency, reactions at the injection site, "withdrawal" syndrome, aftereffect syndrome (decreased performance, muscle weakness), allergic reactions.

Interaction

Valium potentiates the effects of alcohol, anticonvulsants, and antihypertensives, analgesics, sleeping pills. MAO inhibitors, analeptics, psychostimulants reduce activity.

Overdose can cause such symptoms as drowsiness, impaired consciousness, coma, inhibition of reflexes. The treatment is gastric lavage, intravenous fluid, and flumazenil (diazepine antagonist), mechanical ventilation.

Dosage and administration

Adults with neurosis, neurasthenia, hysteria, spastic paralysis, prevention of epileptic seizures take 2-10 mg 3-4 times a day. Withdrawal symptoms in patients with alcoholism require 10 mg 3-4 times on the first day, followed by a daily dose reduction of 5 mg 3-4 times a day. In elderly patients, a single dose is 1-2.5 mg 3-4 times a day. If necessary, the dose is gradually increased. For children older than 6 months, the drug is prescribed in a dose of 1-2.5 mg 3-4 times a day (if necessary, the dose gradually increases).

Special instructions

Mixing Valium with other drugs in the same syringe is not allowed, since the drug may settle on the walls. Avoid getting the solution into the artery and extravasal space. For intravenous administration, only large veins are used in newborns, while equipment for pulmonary resuscitation should be available.

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